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KMID : 0921620210510030138
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Journal of Bacteriology and Virology
2021 Volume.51 No. 3 p.138 ~ p.147
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Isolation and Genomic Analyses of an Early SARS-CoV-2 Strains from the 2020 Epidemic in Gwangju, South Korea
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Kim Min-Ji
Lee Ji-Eun
Kim Tae-Sun
Park Jung-Wook
Lim Mi-Hyeon
Hwang Da-Jeong
Jeong Jin
Kim Kwang-Gon
Yoon Ji-Eun
Kee Hye-Young
Park Jong-Jin
Seo Jin-Jong
Chung Jae-Keun
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Abstract
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Since the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in late December 2019, the coronavirus disease 2019 (COVID-19) has spread fast around the world. RNA viruses, including SARS-CoV-2, have higher gene mutations than DNA viruses during virus replication. Variations in SARS-CoV-2 genome could contribute to efficiency of viral spread and severity of COVID-19. In this study, we analyzed the locations of genomic mutations to investigate the genetic diversity among isolates of SARS-CoV-2 in Gwangju. We detected non-synonymous and frameshift mutations in various parts of SARS-CoV-2 genome. The phylogenetic analysis for whole genome showed that SARS-CoV-2 genomes in Gwangju isolates are clustered within clade V and G. Our findings not only provide a glimpse into changes of prevalent virus clades in Gwangju, South Korea, but also support genomic surveillance of SARS-CoV-2 to aid in the development of efficient therapeutic antibodies and vaccines against COVID-19.
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KEYWORD
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SARS-COV-2, Whole-genome sequencing, Genomic mutation, Gwangju
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